Research workbench
Crystal structure of the TIM9 TIM10 hexameric complex
Analyse Crystal structure of the TIM9 TIM10 hexameric complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2BSK
- Type
- protein
- Length
- 434 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitochondrial import inner membrane translocase subunit TIM9 a; Mitochondrial import…
- UniProt
- Q9Y5J7, P62072
- Pockets
- 9 · best druggability 0.47
Structure
x-ray diffraction · 6 distinct chains · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitochondrial import inner membrane translocase subunit TIM9 a | protein | 73 | 77% helix, 0% strand | Q9Y5J7 |
| B | Mitochondrial import inner membrane translocase subunit TIM10 | protein | 65 | 69% helix, 0% strand | P62072 |
| C | Mitochondrial import inner membrane translocase subunit TIM9 a | protein | 79 | 61% helix, 0% strand | Q9Y5J7 |
| D | Mitochondrial import inner membrane translocase subunit TIM10 | protein | 90 | 71% helix, 0% strand | P62072 |
| E | Mitochondrial import inner membrane translocase subunit TIM9 a | protein | 63 | 76% helix, 0% strand | Q9Y5J7 |
| F | Mitochondrial import inner membrane translocase subunit TIM10 | protein | 64 | 77% helix, 0% strand | P62072 |
Pockets
9 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 188 | 0.47 | 0.75 | 29 | empty |
| 2 | 140 | 0.40 | 0.74 | 25 | empty |
| 3 | 128 | 0.39 | 0.74 | 18 | empty |
| 4 | 90 | 0.38 | 0.76 | 19 | empty |
| 5 | 79 | 0.36 | 0.76 | 13 | empty |
Interfaces
9 interfaces between chains.
- B–E · 1372 Ų buried · 9 hydrogen bonds · protein-protein
- C–F · 1313 Ų buried · 9 hydrogen bonds · protein-protein
- A–D · 1249 Ų buried · 12 hydrogen bonds · protein-protein
- A–B · 1075 Ų buried · 12 hydrogen bonds · protein-protein
- E–F · 1038 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 19 modified, 12 disulfide (engineered, disulfide).
Compared structures
- 2BSK · Crystal structure of the TIM9 Tim10 hexameric complex · the same entry in another collection · chain F against F, TM-score 1.00
- P62072 · AlphaFold monomer V2.0 prediction for mitochondrial import inner membrane translocase… · a predicted model of the same protein · chain F against A, TM-score 0.94
- Q9Y5J7 · AlphaFold monomer V2.0 prediction for mitochondrial import inner membrane translocase… · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y5J7
- Every structure of UniProt P62072
- Elsewhere: RCSB PDB 2BSK · PDBe 2BSK · UniProt Q9Y5J7 · UniProt P62072
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