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Structure of murine dectin-1

Analyse Structure of murine dectin-1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2BPD
Type: protein
Length: 256 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dectin-1
UniProt: Q6QLQ4
Pockets: 1 · best druggability 0.55

Structure

x-ray diffraction · 2 distinct chains · 19% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Dectin-1	protein	127	19% helix, 35% strand	Q6QLQ4
B	Dectin-1	protein	129	19% helix, 33% strand	Q6QLQ4

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	72	0.55	0.87	17	empty

Interfaces

1 interface between chains.

A–B · 619 Å² buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

2BPD · Structure of murine dectin-1 · the same entry in another collection · chain A against A, TM-score 1.00
Q6QLQ4 · AlphaFold monomer V2.0 prediction for C-type lectin domain family 7 member a (Q6QLQ4) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6QLQ4
Elsewhere: RCSB PDB 2BPD · PDBe 2BPD · UniProt Q6QLQ4

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