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Molecular insights into PEBP2/CBF-smmhc associated acute leukemia revealed from the three-dimensional structure of PEBP2/CBF beta

Analyse Molecular insights into PEBP2/CBF-smmhc associated acute leukemia revealed from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1CL3
Type: protein
Length: 138 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Polyomavirus enhancer binding protein 2
UniProt: Q13951
Pockets: 2 · best druggability 0.63

Structure

solution nmr · 1 distinct chain · 30% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Polyomavirus enhancer binding protein 2	protein	138	30% helix, 26% strand	Q13951

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	96	0.63	0.88	17	empty
2	97	0.40	0.77	19	empty

Compared structures

1CL3 · Molecular insights into PEBP2/CBF-smmhc associated acute leukemia revealed from the… · the same entry in another collection · chain A against A, TM-score 1.00
Q13951 · AlphaFold monomer V2.0 prediction for core-binding factor subunit beta (Q13951) · a predicted model of the same protein · chain A against A, TM-score 0.70

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13951
Elsewhere: RCSB PDB 1CL3 · PDBe 1CL3 · UniProt Q13951

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