Research workbench
LACTALDEHYDE:1,2-propanediol oxidoreductase of escherichia COLI
Analyse LACTALDEHYDE:1,2-propanediol oxidoreductase of escherichia COLI in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2BI4
- Type
- protein
- Length
- 764 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lactaldehyde reductase
- EC
- 1.1.1.77
- UniProt
- P11549
- Ligands
- NAD, FE, CL
- Pockets
- 4 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 52% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Lactaldehyde reductase (EC 1.1.1.77) | protein | 382 | 52% helix, 11% strand | P11549 |
Ligands and binding sites
- NAD · Nicotinamide-adenine-dinucleotide · ligand · 2 copies · chains A, B
- FE · Fe (III) ion · metal · 2 copies · chains A, B
- CL · Chloride ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 575 | 0.73 | 0.81 | 70 | NAD |
| 2 | 582 | 0.72 | 0.80 | 75 | NAD |
| 3 | 280 | 0.61 | 0.79 | 54 | empty |
| 4 | 371 | 0.60 | 0.77 | 39 | empty |
Interfaces
1 interface between chains.
- A–B · 1149 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 2BI4 · Lactaldehyde:1,2-propanediol oxidoreductase of Escherichia coli · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11549
- Elsewhere: RCSB PDB 2BI4 · PDBe 2BI4 · UniProt P11549
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.