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Crystal structure of rat A1B1 integrin I-domain.

Analyse Crystal structure of rat A1B1 integrin I-domain. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1CK4
Type: protein
Length: 386 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Integrin alpha-1
UniProt: P18614
Pockets: 2 · best druggability 0.63

Structure

x-ray diffraction · 2 distinct chains · 41% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Integrin alpha-1	protein	192	41% helix, 20% strand	P18614
B	Integrin alpha-1	protein	194	41% helix, 21% strand	P18614

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	218	0.63	0.83	31	empty
2	118	0.38	0.74	26	empty

Interfaces

1 interface between chains.

A–B · 531 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

1CK4 · Crystal structure of rat A1B1 integrin I-domain. · the same entry in another collection · chain A against A, TM-score 1.00
P18614 · AlphaFold monomer V2.0 prediction for integrin alpha-1 (P18614) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P18614
Elsewhere: RCSB PDB 1CK4 · PDBe 1CK4 · UniProt P18614

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