Research workbench
Structure of HIV-1 protease mutant bound to ritonavir
Analyse Structure of HIV-1 protease mutant bound to ritonavir in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2B60
- Type
- protein
- Length
- 198 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gag-pol polyprotein
- UniProt
- Q7SMT3
- Ligands
- RIT
- Pockets
- 1 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 4% helix, 54% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Gag-pol polyprotein | protein | 99 | 4% helix, 54% strand | Q7SMT3 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 425 | 0.68 | 0.80 | 40 | RIT |
Interfaces
1 interface between chains.
- A–B · 1852 Ų buried · 37 hydrogen bonds · protein-protein
Compared structures
- 2B60 · Structure of HIV-1 protease mutant bound to Ritonavir · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7SMT3
- Elsewhere: RCSB PDB 2B60 · PDBe 2B60 · UniProt Q7SMT3
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