Research workbench
Crystal structure of the norwalk virus RNA dependent RNA polymerase from strain HU/NLV/DRESDEN174/1997/GE
Analyse Crystal structure of the norwalk virus RNA dependent RNA polymerase from strain… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2B43
- Type
- protein
- Length
- 2,004 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Non-structural polyprotein
- UniProt
- Q6REV3
- Pockets
- 20 · best druggability 0.83
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Non-structural polyprotein | protein | 501 | 41% helix, 16% strand | Q6REV3 |
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1047 | 0.83 | 0.84 | 113 | empty |
| 2 | 931 | 0.72 | 0.76 | 70 | empty |
| 3 | 1006 | 0.72 | 0.76 | 76 | empty |
| 4 | 977 | 0.71 | 0.75 | 78 | empty |
| 5 | 924 | 0.70 | 0.75 | 78 | empty |
Interfaces
6 interfaces between chains.
- B–D · 931 Ų buried · 14 hydrogen bonds · protein-protein
- A–C · 906 Ų buried · 19 hydrogen bonds · protein-protein
- B–C · 640 Ų buried · 9 hydrogen bonds · protein-protein
- A–D · 632 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 31 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2B43 · Crystal structure of the Norwalk virus RNA dependent RNA polymerase from strain… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6REV3
- Elsewhere: RCSB PDB 2B43 · PDBe 2B43 · UniProt Q6REV3
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