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Structure of azurin from alcaligenes denitrificans. refinement at 1.8 ångströms resolution and comparison of the two crystallographically independent molecules

Analyse Structure of azurin from alcaligenes denitrificans. refinement at 1.8 ångströms… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2AZA
Type: protein
Length: 258 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Azurin
UniProt: P00280
Ligands: CU, SO4
Pockets: 2 · best druggability 0.47

Structure

x-ray diffraction · 1 distinct chain · 16% helix, 36% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Azurin	protein	129	16% helix, 36% strand	P00280

Ligands and binding sites

CU · Copper (II) ion · metal · 2 copies · chains A, B
SO4 · Sulfate ion · ion · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	74	0.47	0.83	17	empty
2	53	0.43	0.83	19	empty

Interfaces

1 interface between chains.

A–B · 526 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

2AZA · Structure of azurin from alcaligenes denitrificans. refinement at 1.8 ångströms… · the same entry in another collection · chain A against A, TM-score 1.00
P00280 · AlphaFold monomer V2.0 prediction for azurin (P00280) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00280
Elsewhere: RCSB PDB 2AZA · PDBe 2AZA · UniProt P00280

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