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Flock house virus B2-dsrna complex (P4122)

Analyse Flock house virus B2-dsrna complex (P4122) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
2AZ2
Type
protein + RNA
Length
176 residues
Chains
4
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
5'-R(*GP*CP*AP*(5BU)P*GP*GP*AP*CP*GP*CP*GP*(5BU) P*CP*CP*AP*(5BU)P*GP*C)-3'; B2 protein
UniProt
P68831
Pockets
1 · best druggability 0.64

Structure

x-ray diffraction · 2 distinct chains · 76% helix, 0% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
C, D5'-R(*GP*CP*AP*(5BU)P*GP*GP*AP*CP*GP*CP*GP*(5BU) P*CP*CP*AP*(5BU)P*GP*C)-3'rna18——
A, BB2 proteinprotein7076% helix, 0% strandP68831

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
16660.640.7534empty

Interfaces

6 interfaces between chains.

  • A–B · 1504 Ų buried · 10 hydrogen bonds · protein-protein
  • C–D · 871 Ų buried · 74 hydrogen bonds · nucleic-nucleic
  • D–A · 398 Ų buried · 6 hydrogen bonds · protein-nucleic
  • C–B · 398 Ų buried · 5 hydrogen bonds · protein-nucleic
  • C–A · 340 Ų buried · 7 hydrogen bonds · protein-nucleic

Modifications

Observed in the structure: 6 modified (nucleotide modification).

Compared structures

  • 2AZ2 · Flock House virus B2-dsRNA Complex (P4122) · the same entry in another collection · chain C against C, TM-score 1.00

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