Research workbench

Heparin-linked biologically-active dimer of fibroblast growth factor

Analyse Heparin-linked biologically-active dimer of fibroblast growth factor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2AXM
Type: protein
Length: 257 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Acidic fibroblast growth factor
UniProt: P05230
Ligands: SGN, IDS

Structure

x-ray diffraction · 2 distinct chains · 9% helix, 43% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Acidic fibroblast growth factor	protein	130	9% helix, 43% strand	P05230
B	Acidic fibroblast growth factor	protein	127	9% helix, 43% strand	P05230

Ligands and binding sites

SGN · 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose · sugar · 3 copies · chains A, B
IDS · 2-O-sulfo-alpha-L-idopyranuronic acid · sugar · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 15 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

2AXM · Heparin-linked biologically-active dimer of fibroblast growth factor · the same entry in another collection · chain A against A, TM-score 1.00
P05230 · AlphaFold monomer V2.0 prediction for fibroblast growth factor 1 (P05230) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P05230
Elsewhere: RCSB PDB 2AXM · PDBe 2AXM · UniProt P05230

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.