Research workbench
Crystal structures of T cell receptor beta chains related to rheumatoid arthritis
Analyse Crystal structures of T cell receptor beta chains related to rheumatoid… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2AXH
- Type
- protein
- Length
- 484 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- T cell receptor beta chain
- UniProt
- P01850
- Pockets
- 5 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 5% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | T cell receptor beta chain | protein | 242 | 5% helix, 48% strand | P01850 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 343 | 0.62 | 0.78 | 47 | empty |
| 2 | 56 | 0.61 | 0.92 | 24 | empty |
| 3 | 279 | 0.59 | 0.78 | 37 | empty |
| 4 | 101 | 0.37 | 0.75 | 24 | empty |
| 5 | 87 | 0.37 | 0.76 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1754 Ų buried · 20 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide, 4 modified (disulfide, engineered).
Compared structures
- 2AXH · Crystal structures of T cell receptor beta chains related to rheumatoid arthritis · the same entry in another collection · chain A against A, TM-score 1.00
- P01850 · AlphaFold monomer V2.0 prediction for T cell receptor beta constant 1 (P01850) · a predicted model of the same protein · chain A against A, TM-score 0.53
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01850
- Elsewhere: RCSB PDB 2AXH · PDBe 2AXH · UniProt P01850
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