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Synapse associated protein 97 PDZ2 domain variant C378G

Analyse Synapse associated protein 97 PDZ2 domain variant C378G in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2AWU
Type: protein
Length: 188 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Synapse-associated protein 97; Ahh
UniProt: Q62696
Pockets: 1 · best druggability 0.25

Structure

x-ray diffraction · 3 distinct chains · 15% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Synapse-associated protein 97	protein	95	15% helix, 40% strand	Q62696
B	Synapse-associated protein 97	protein	90	16% helix, 41% strand	Q62696
C	Ahh	protein	3	0% helix, 0% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	56	0.25	0.72	19	empty

Interfaces

2 interfaces between chains.

B–C · 263 Å² buried · 5 hydrogen bonds · protein-protein
A–B · 129 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

2AWU · Synapse associated protein 97 PDZ2 domain variant C378G · the same entry in another collection · chain A against A, TM-score 1.00
Q62696 · AlphaFold monomer V2.0 prediction for disks large homolog 1 (Q62696) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q62696
Elsewhere: RCSB PDB 2AWU · PDBe 2AWU · UniProt Q62696

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