Research workbench
Structure of prgx Y153C mutant
Analyse Structure of prgx Y153C mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2AWI
- Type
- protein
- Length
- 3,562 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Prgx
- UniProt
- Q04114
- Pockets
- 20 · best druggability 0.79
Structure
x-ray diffraction · 3 distinct chains · 73% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, I | Prgx | protein | 298 | 72% helix, 1% strand | Q04114 |
| C, D, E, F | Prgx | protein | 297 | 72% helix, 1% strand | Q04114 |
| G, H, J, K, L | Prgx | protein | 296 | 74% helix, 1% strand | Q04114 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 918 | 0.79 | 0.82 | 71 | empty |
| 2 | 1133 | 0.79 | 0.81 | 102 | empty |
| 3 | 927 | 0.79 | 0.81 | 76 | empty |
| 4 | 939 | 0.79 | 0.81 | 84 | empty |
| 5 | 939 | 0.79 | 0.81 | 73 | empty |
Interfaces
19 interfaces between chains.
- A–B · 2992 Ų buried · 39 hydrogen bonds · protein-protein
- E–F · 2986 Ų buried · 38 hydrogen bonds · protein-protein
- G–H · 2921 Ų buried · 38 hydrogen bonds · protein-protein
- K–L · 2902 Ų buried · 42 hydrogen bonds · protein-protein
- C–D · 2888 Ų buried · 42 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 48 modified (engineered).
Compared structures
- 2AWI · Structure of PrgX Y153C mutant · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q04114
- Elsewhere: RCSB PDB 2AWI · PDBe 2AWI · UniProt Q04114
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