Research workbench
Structure of the plasmodium mtip-myoa complex, a key component of the parasite invasion motor
Analyse Structure of the plasmodium mtip-myoa complex, a key component of the parasite… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2AUC
- Type
- protein
- Length
- 366 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin a tail interacting protein; Myosin a
- Pockets
- 6 · best druggability 0.72
Structure
x-ray diffraction · 4 distinct chains · 63% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myosin a tail interacting protein | protein | 116 | 63% helix, 5% strand | — |
| B | Myosin a tail interacting protein | protein | 111 | 63% helix, 4% strand | — |
| C | Myosin a tail interacting protein | protein | 126 | 60% helix, 6% strand | — |
| D | Myosin a | protein | 13 | 77% helix, 0% strand | — |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 848 | 0.72 | 0.77 | 83 | empty |
| 2 | 358 | 0.65 | 0.80 | 31 | empty |
| 3 | 197 | 0.56 | 0.79 | 41 | empty |
| 4 | 53 | 0.42 | 0.82 | 11 | empty |
| 5 | 70 | 0.41 | 0.79 | 16 | empty |
Interfaces
5 interfaces between chains.
- A–C · 902 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 728 Ų buried · 6 hydrogen bonds · protein-protein
- C–D · 714 Ų buried · 12 hydrogen bonds · protein-protein
- A–B · 442 Ų buried · 7 hydrogen bonds · protein-protein
- A–D · 36 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 14 modified (engineered, acetylation).
Compared structures
- 2AUC · Structure of the Plasmodium MTIP-MyoA complex, a key component of the parasite invasion… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2AUC · PDBe 2AUC
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