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Structure of a mycobacterium tuberculosis nusa-RNA complex

Analyse Structure of a mycobacterium tuberculosis nusa-RNA complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2ATW
Type: protein + RNA
Length: 472 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ribosomal RNA (5'- agaacucaauag -3'); Transcription elongation protein nusa
UniProt: P0A5M2
Pockets: 2 · best druggability 0.40

Structure

x-ray diffraction · 3 distinct chains · 31% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, D	Ribosomal RNA (5'- agaacucaauag -3')	rna	12	—	—
A	Transcription elongation protein nusa	protein	223	32% helix, 33% strand	P0A5M2
C	Transcription elongation protein nusa	protein	225	31% helix, 32% strand	P0A5M2

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	73	0.40	0.80	16	empty
2	55	0.40	0.82	15	empty

Interfaces

2 interfaces between chains.

D–C · 1320 Å² buried · 29 hydrogen bonds · protein-nucleic
B–A · 1302 Å² buried · 30 hydrogen bonds · protein-nucleic

Compared structures

2ATW · Structure of a Mycobacterium tuberculosis NusA-RNA complex · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0A5M2
Elsewhere: RCSB PDB 2ATW · PDBe 2ATW · UniProt P0A5M2

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