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Crystal structure of PH1915 (apc 5817): a hypothetical RNA methyltransferase

Analyse Crystal structure of PH1915 (apc 5817): a hypothetical RNA methyltransferase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2AS0
Type: protein
Length: 792 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hypothetical protein PH1915
EC: 2.1.1.-
UniProt: O59578
Pockets: 8 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Hypothetical protein PH1915 (EC 2.1.1.-)	protein	396	34% helix, 31% strand	O59578

Pockets

8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1019	0.82	0.83	103	empty
2	1191	0.79	0.81	86	empty
3	282	0.61	0.79	45	empty
4	184	0.59	0.82	30	empty
5	207	0.50	0.76	21	empty

Interfaces

1 interface between chains.

A–B · 1967 Å² buried · 20 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 28 modified (engineered).

Compared structures

2AS0 · Crystal Structure of PH1915 (APC 5817): A Hypothetical RNA Methyltransferase · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O59578
Elsewhere: RCSB PDB 2AS0 · PDBe 2AS0 · UniProt O59578

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