Research workbench
Human plasminogen activator inhibitor-2.[LOOP (66-98) deletion mutant] complexed with peptide N-acetyl-teaaagdggvmtgr-oh
Analyse Human plasminogen activator inhibitor-2.[LOOP (66-98) deletion mutant]… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2ARQ
- Type
- protein
- Length
- 374 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Plasminogen activator inhibitor-2; 14-mer from plasminogen activator inhibitor-2
- UniProt
- P05120
- Ligands
- ACE
- Pockets
- 1 · best druggability 0.34
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Plasminogen activator inhibitor-2 | protein | 360 | 31% helix, 34% strand | P05120 |
| P | 14-mer from plasminogen activator inhibitor-2 | protein | 14 | 0% helix, 86% strand | P05120 |
Ligands and binding sites
- ACE · Acetyl group · ligand · chains A, P
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 56 | 0.34 | 0.78 | 14 | empty |
Interfaces
1 interface between chains.
- A–P · 1343 Ų buried · 50 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 covalent, 1 disulfide (covalent ligand, disulfide).
Compared structures
- 2ARQ · Human plasminogen activator inhibitor-2.[loop (66-98) deletion mutant] complexed with… · the same entry in another collection · chain A against A, TM-score 1.00
- P05120 · AlphaFold monomer V2.0 prediction for plasminogen activator inhibitor 2 (P05120) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05120
- Elsewhere: RCSB PDB 2ARQ · PDBe 2ARQ · UniProt P05120
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.