Research workbench
Single chain fv of C219 in complex with synthetic epitope peptide
Analyse Single chain fv of C219 in complex with synthetic epitope peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2AP2
- Type
- protein
- Length
- 503 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Single chain fv; P-glycoprotein
- UniProt
- Q6KB05, Q505N9
- Pockets
- 2 · best druggability 0.39
Structure
x-ray diffraction · 4 distinct chains · 9% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Single chain fv | protein | 238 | 5% helix, 47% strand | Q6KB05, Q505N9 |
| C | Single chain fv | protein | 240 | 5% helix, 48% strand | Q6KB05, Q505N9 |
| P | P-glycoprotein | protein | 11 | 82% helix, 0% strand | — |
| Q | P-glycoprotein | protein | 14 | 79% helix, 0% strand | — |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 89 | 0.39 | 0.77 | 21 | empty |
| 2 | 103 | 0.36 | 0.74 | 21 | empty |
Interfaces
2 interfaces between chains.
- C–Q · 556 Ų buried · 8 hydrogen bonds · protein-protein
- A–P · 453 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 2AP2 · Single chain fv of C219 in complex with synthetic epitope peptide · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6KB05
- Every structure of UniProt Q505N9
- Elsewhere: RCSB PDB 2AP2 · PDBe 2AP2 · UniProt Q6KB05 · UniProt Q505N9
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