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X-ray structure of an ankyrin repeat family protein Q5ZSV0 from legionella pneumophila. northeast structural genomics consortium target LGR21.

Analyse X-ray structure of an ankyrin repeat family protein Q5ZSV0 from legionella… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2AJA
Type: protein
Length: 688 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ankyrin repeat family protein
UniProt: Q5ZSV0
Pockets: 8 · best druggability 0.75

Structure

x-ray diffraction · 2 distinct chains · 65% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ankyrin repeat family protein	protein	343	63% helix, 1% strand	Q5ZSV0
B	Ankyrin repeat family protein	protein	345	67% helix, 2% strand	Q5ZSV0

Pockets

8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	980	0.75	0.78	93	empty
2	720	0.73	0.79	65	empty
3	87	0.72	0.95	20	empty
4	66	0.71	0.96	20	empty
5	56	0.44	0.83	15	empty

Interfaces

1 interface between chains.

A–B · 1357 Å² buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 16 modified (engineered).

Compared structures

2AJA · X-Ray structure of an ankyrin repeat family protein Q5ZSV0 from Legionella pneumophila.… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5ZSV0
Elsewhere: RCSB PDB 2AJA · PDBe 2AJA · UniProt Q5ZSV0

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