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X-ray crystal structure of R46A,R161A mutant of mycobacterium tuberculosis fabh

Analyse X-ray crystal structure of R46A,R161A mutant of mycobacterium tuberculosis fabh in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2AHB
Type: protein
Length: 668 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta- ketoacyl-acp synthase III
EC: 2.3.1.41
UniProt: P0A574
Pockets: 6 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Beta- ketoacyl-acp synthase III (EC 2.3.1.41)	protein	334	37% helix, 25% strand	P0A574

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	116	0.80	0.99	26	empty
2	119	0.57	0.83	23	empty
3	151	0.43	0.75	35	empty
4	96	0.43	0.79	17	empty
5	89	0.35	0.75	20	empty

Interfaces

1 interface between chains.

A–B · 3087 Å² buried · 37 hydrogen bonds · protein-protein

Compared structures

2AHB · X-ray crystal structure of R46A,R161A mutant of Mycobacterium tuberculosis FabH · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0A574
Elsewhere: RCSB PDB 2AHB · PDBe 2AHB · UniProt P0A574

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