Research workbench
Glutaryl 7-aminocephalosporanic acid acylase: mutational study of activation mechanism
Analyse Glutaryl 7-aminocephalosporanic acid acylase: mutational study of activation… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2AE4
- Type
- protein
- Length
- 682 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutaryl 7-aminocephalosporanic acid acylase
- EC
- 3.5.1.11
- Ligands
- SO4
- Pockets
- 6 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutaryl 7-aminocephalosporanic acid acylase (EC 3.5.1.11) | protein | 160 | 66% helix, 6% strand | — |
| B | Glutaryl 7-aminocephalosporanic acid acylase (EC 3.5.1.11) | protein | 522 | 25% helix, 29% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 976 | 0.72 | 0.76 | 98 | GOL, SO4 |
| 2 | 158 | 0.51 | 0.79 | 23 | empty |
| 3 | 75 | 0.38 | 0.78 | 18 | empty |
| 4 | 98 | 0.35 | 0.74 | 25 | empty |
| 5 | 64 | 0.33 | 0.75 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 4271 Ų buried · 57 hydrogen bonds · protein-protein
Compared structures
- 2AE4 · Glutaryl 7-Aminocephalosporanic Acid Acylase: mutational study of activation mechanism · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2AE4 · PDBe 2AE4
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