Research workbench
Structure of D166A arginine deiminase
Analyse Structure of D166A arginine deiminase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2ACI
- Type
- protein
- Length
- 1,620 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Arginine deiminase
- EC
- 3.5.3.6
- UniProt
- P13981
- Pockets
- 18 · best druggability 0.85
Structure
x-ray diffraction · 4 distinct chains · 35% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Arginine deiminase (EC 3.5.3.6) | protein | 402 | 34% helix, 21% strand | P13981 |
| B | Arginine deiminase (EC 3.5.3.6) | protein | 409 | 36% helix, 22% strand | P13981 |
| C | Arginine deiminase (EC 3.5.3.6) | protein | 403 | 36% helix, 23% strand | P13981 |
| D | Arginine deiminase (EC 3.5.3.6) | protein | 406 | 35% helix, 22% strand | P13981 |
Pockets
18 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 820 | 0.85 | 0.87 | 111 | empty |
| 2 | 611 | 0.80 | 0.86 | 64 | empty |
| 3 | 926 | 0.80 | 0.82 | 89 | empty |
| 4 | 642 | 0.80 | 0.85 | 71 | empty |
| 5 | 150 | 0.79 | 0.96 | 23 | empty |
Interfaces
4 interfaces between chains.
- B–C · 1859 Ų buried · 18 hydrogen bonds · protein-protein
- A–D · 1811 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 983 Ų buried · 15 hydrogen bonds · protein-protein
- C–D · 974 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13981
- Elsewhere: RCSB PDB 2ACI · PDBe 2ACI · UniProt P13981
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