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Crystal structure of the ISHP608 transposase in complex with stem-loop DNA

Analyse Crystal structure of the ISHP608 transposase in complex with stem-loop DNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
2A6O
Type
protein + DNA
Length
348 residues
Chains
4
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
5'-D(*CP*CP*CP*CP*TP*AP*GP*CP*TP*TP*TP*AP*GP*CP*TP*AP*TP*GP *GP*GP*GP*A)-3'; ISHP608…
UniProt
Q933Z0
Pockets
3 · best druggability 0.67

Structure

x-ray diffraction · 2 distinct chains · 41% helix, 24% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
C, D5'-D(*CP*CP*CP*CP*TP*AP*GP*CP*TP*TP*TP*AP*GP*CP*TP*AP*TP*GP *GP*GP*GP*A)-3'dna22——
A, BISHP608 transposaseprotein15241% helix, 24% strandQ933Z0

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
13750.670.8137empty
23710.670.8139empty
34340.620.7749empty

Interfaces

5 interfaces between chains.

  • A–B · 1932 Ų buried · 34 hydrogen bonds · protein-protein
  • C–A · 614 Ų buried · 13 hydrogen bonds · protein-nucleic
  • D–B · 609 Ų buried · 14 hydrogen bonds · protein-nucleic
  • C–B · 524 Ų buried · 9 hydrogen bonds · protein-nucleic
  • D–A · 510 Ų buried · 9 hydrogen bonds · protein-nucleic

Compared structures

  • 2A6O · Crystal Structure of the ISHp608 Transposase in Complex with Stem-loop DNA · the same entry in another collection · chain C against C, TM-score 1.00

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