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Crystal structure of isochorismatase family protein

Analyse Crystal structure of isochorismatase family protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2A67
Type: protein
Length: 667 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Isochorismatase family protein
UniProt: Q82ZG7
Pockets: 8 · best druggability 0.64

Structure

x-ray diffraction · 2 distinct chains · 32% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Isochorismatase family protein	protein	166	31% helix, 23% strand	Q82ZG7
B, C, D	Isochorismatase family protein	protein	167	32% helix, 23% strand	Q82ZG7

Pockets

8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	370	0.64	0.79	26	empty
2	143	0.45	0.76	18	empty
3	92	0.39	0.77	16	empty
4	99	0.38	0.76	17	empty
5	99	0.38	0.75	16	empty

Interfaces

3 interfaces between chains.

B–C · 1071 Å² buried · 16 hydrogen bonds · protein-protein
A–D · 1062 Å² buried · 16 hydrogen bonds · protein-protein
A–C · 236 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 12 modified (engineered).

Compared structures

2A67 · Crystal structure of Isochorismatase family protein · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q82ZG7
Elsewhere: RCSB PDB 2A67 · PDBe 2A67 · UniProt Q82ZG7

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