Research workbench
Human cyclin-dependent kinase 2 in complex with roscovitine
Analyse Human cyclin-dependent kinase 2 in complex with roscovitine in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2A4L
- Type
- protein
- Length
- 286 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Homo sapiens cyclin-dependent kinase 2
- EC
- 2.7.1.37
- Ligands
- RRC
- Pockets
- 2 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Homo sapiens cyclin-dependent kinase 2 (EC 2.7.1.37) | protein | 286 | 34% helix, 15% strand | — |
Ligands and binding sites
- RRC · R-roscovitine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 350 | 0.73 | 0.84 | 46 | RRC |
| 2 | 65 | 0.30 | 0.74 | 16 | empty |
Compared structures
- 2A4L · Human cyclin-dependent kinase 2 in complex with roscovitine · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2A4L · PDBe 2A4L
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