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Structure of the mutant VAL169CYS of catalase hpii from escherichia COLI

Analyse Structure of the mutant VAL169CYS of catalase hpii from escherichia COLI in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1CF9
Type: protein
Length: 2,908 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (catalase hpii)
EC: 1.11.1.6
UniProt: P21179
Ligands: HEM
Pockets: 20 · best druggability 0.89

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Protein (catalase hpii) (EC 1.11.1.6)	protein	727	32% helix, 18% strand	P21179

Ligands and binding sites

HEM · Protoporphyrin IX containing Fe · ligand · 4 copies · chains A, D, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	513	0.89	0.96	62	empty
2	506	0.89	0.96	59	empty
3	322	0.86	0.96	51	HEM
4	320	0.86	0.96	51	HEM
5	477	0.86	0.93	55	empty

Interfaces

6 interfaces between chains.

A–D · 6171 Å² buried · 119 hydrogen bonds · protein-protein
B–C · 6128 Å² buried · 116 hydrogen bonds · protein-protein
B–D · 5949 Å² buried · 78 hydrogen bonds · protein-protein
A–C · 5865 Å² buried · 84 hydrogen bonds · protein-protein
C–D · 2259 Å² buried · 43 hydrogen bonds · protein-protein

Compared structures

1CF9 · Structure of the mutant VAL169CYS of catalase HPII from Escherichia coli · the same entry in another collection · chain A against A, TM-score 1.00
P21179 · AlphaFold monomer V2.0 prediction for catalase hpii (P21179) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P21179
Elsewhere: RCSB PDB 1CF9 · PDBe 1CF9 · UniProt P21179

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