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Solution structure of the F-actin binding domain of BCR-ABL/C-abl

Analyse Solution structure of the F-actin binding domain of BCR-ABL/C-abl in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1ZZP
Type: protein
Length: 109 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Proto-oncogene tyrosine-protein kinase ABL1
EC: 2.7.1.112
UniProt: P00519
Pockets: 1 · best druggability 0.34

Structure

solution nmr · 1 distinct chain · 64% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.1.112)	protein	109	64% helix, 0% strand	P00519

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	96	0.34	0.74	16	empty

Compared structures

1ZZP · Solution structure of the F-actin binding domain of Bcr-Abl/c-Abl · the same entry in another collection · chain A against A, TM-score 1.00
P00519 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase ABL1 (P00519) · a predicted model of the same protein · chain A against A, TM-score 0.46

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00519
Elsewhere: RCSB PDB 1ZZP · PDBe 1ZZP · UniProt P00519

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