Research workbench
Structural model of complex of BCL-W protein with bid BH3-peptide
Analyse Structural model of complex of BCL-W protein with bid BH3-peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ZY3
- Type
- protein
- Length
- 190 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Apoptosis regulator BCL-W; BH3-peptide from BH3 interacting domain death agonist protein
- UniProt
- Q92843, P55957
- Pockets
- 4 · best druggability 0.65
Structure
solution nmr · 2 distinct chains · 59% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Apoptosis regulator BCL-W | protein | 170 | 58% helix, 0% strand | Q92843 |
| B | BH3-peptide from BH3 interacting domain death agonist protein | protein | 20 | 75% helix, 0% strand | P55957 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 183 | 0.65 | 0.85 | 32 | empty |
| 2 | 195 | 0.59 | 0.81 | 27 | empty |
| 3 | 69 | 0.42 | 0.80 | 14 | empty |
| 4 | 71 | 0.33 | 0.75 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1155 Ų buried · 27 hydrogen bonds · protein-protein
Compared structures
- 1ZY3 · Structural model of complex of Bcl-w protein with Bid BH3-peptide · the same entry in another collection · chain A against A, TM-score 1.00
- Q92843 · AlphaFold monomer V2.0 prediction for BCL-2-like protein 2 (Q92843) · a predicted model of the same protein · chain A against A, TM-score 0.62
- P55957 · AlphaFold monomer V2.0 prediction for BH3-interacting domain death agonist (P55957) · a predicted model of the same protein · chain B against A, TM-score 0.53
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q92843
- Every structure of UniProt P55957
- Elsewhere: RCSB PDB 1ZY3 · PDBe 1ZY3 · UniProt Q92843 · UniProt P55957
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.