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Crystal structure of the phosphorylated receiver domain of the transcription regulator NTRC1 from aquifex aeolicus
Analyse Crystal structure of the phosphorylated receiver domain of the transcription… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ZY2
- Type
- protein
- Length
- 265 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcriptional regulator NTRC1
- UniProt
- O67198
- Ligands
- MG
- Pockets
- 2 · best druggability 0.47
Structure
x-ray diffraction · 2 distinct chains · 49% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcriptional regulator NTRC1 | protein | 140 | 51% helix, 18% strand | O67198 |
| B | Transcriptional regulator NTRC1 | protein | 125 | 48% helix, 18% strand | O67198 |
Ligands and binding sites
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 233 | 0.47 | 0.74 | 29 | empty |
| 2 | 77 | 0.34 | 0.75 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 509 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
- 1ZY2 · Crystal structure of the phosphorylated receiver domain of the transcription regulator… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O67198
- Elsewhere: RCSB PDB 1ZY2 · PDBe 1ZY2 · UniProt O67198
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