Research workbench
Anthranilate phosphoribosyltransferase from sulfolobus solfataricus in complex with prpp and magnesium
Analyse Anthranilate phosphoribosyltransferase from sulfolobus solfataricus in complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ZXY
- Type
- protein
- Length
- 1,376 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Anthranilate phosphoribosyltransferase
- EC
- 2.4.2.18
- UniProt
- P50384
- Ligands
- PRP, MG
- Pockets
- 8 · best druggability 0.80
Structure
x-ray diffraction · 1 distinct chain · 53% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Anthranilate phosphoribosyltransferase (EC 2.4.2.18) | protein | 344 | 53% helix, 13% strand | P50384 |
Ligands and binding sites
- PRP · 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose · ligand · 4 copies · chains A, B, C, D
- MG · Magnesium ion · metal · 8 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 591 | 0.80 | 0.86 | 53 | MG, PRP |
| 2 | 551 | 0.79 | 0.85 | 50 | MG, PRP |
| 3 | 555 | 0.78 | 0.85 | 55 | MG, PRP |
| 4 | 571 | 0.77 | 0.84 | 51 | MG, PRP |
| 5 | 68 | 0.36 | 0.78 | 11 | empty |
Interfaces
2 interfaces between chains.
- B–C · 952 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 946 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 1ZXY · Anthranilate Phosphoribosyltransferase from Sulfolobus solfataricus in complex with PRPP… · the same entry in another collection · chain A against A, TM-score 1.00
- P50384 · AlphaFold monomer V2.0 prediction for anthranilate phosphoribosyltransferase (P50384) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P50384
- Elsewhere: RCSB PDB 1ZXY · PDBe 1ZXY · UniProt P50384
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