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X-ray crystal structure of protein Q8A1P1 from bacteroides thetaiotaomicron. northeast structural genomics consortium target BTR25.
Analyse X-ray crystal structure of protein Q8A1P1 from bacteroides thetaiotaomicron.… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ZXO
- Type
- protein
- Length
- 1,659 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Conserved hypothetical protein Q8A1P1
- UniProt
- Q8A1P1
- Pockets
- 8 · best druggability 0.81
Structure
x-ray diffraction · 3 distinct chains · 39% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Conserved hypothetical protein Q8A1P1 | protein | 265 | 31% helix, 17% strand | Q8A1P1 |
| F | Conserved hypothetical protein Q8A1P1 | protein | 274 | 39% helix, 17% strand | Q8A1P1 |
| B, D, C, E | Conserved hypothetical protein Q8A1P1 | protein | 280 | 46% helix, 22% strand | Q8A1P1 |
Pockets
8 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1171 | 0.81 | 0.83 | 109 | empty |
| 2 | 1117 | 0.81 | 0.82 | 100 | empty |
| 3 | 483 | 0.76 | 0.84 | 46 | empty |
| 4 | 428 | 0.74 | 0.84 | 54 | empty |
| 5 | 531 | 0.69 | 0.79 | 40 | empty |
Interfaces
3 interfaces between chains.
- A–F · 1238 Ų buried · 21 hydrogen bonds · protein-protein
- C–E · 1230 Ų buried · 22 hydrogen bonds · protein-protein
- B–D · 1224 Ų buried · 24 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 29 modified (engineered).
Compared structures
- 1ZXO · X-ray Crystal Structure of Protein Q8A1P1 from Bacteroides thetaiotaomicron. Northeast… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8A1P1
- Elsewhere: RCSB PDB 1ZXO · PDBe 1ZXO · UniProt Q8A1P1
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