Research workbench
Crystal structure of protein VC0702 from vibrio cholerae
Analyse Crystal structure of protein VC0702 from vibrio cholerae in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ZWY
- Type
- protein
- Length
- 690 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hypothetical UPF0244 protein VC0702
- UniProt
- Q9KU27
- Pockets
- 10 · best druggability 0.86
Structure
x-ray diffraction · 4 distinct chains · 44% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hypothetical UPF0244 protein VC0702 | protein | 165 | 44% helix, 21% strand | Q9KU27 |
| B | Hypothetical UPF0244 protein VC0702 | protein | 180 | 44% helix, 20% strand | Q9KU27 |
| C | Hypothetical UPF0244 protein VC0702 | protein | 172 | 44% helix, 21% strand | Q9KU27 |
| D | Hypothetical UPF0244 protein VC0702 | protein | 173 | 43% helix, 21% strand | Q9KU27 |
Pockets
10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 952 | 0.86 | 0.87 | 113 | empty |
| 2 | 77 | 0.61 | 0.90 | 22 | empty |
| 3 | 75 | 0.61 | 0.89 | 22 | empty |
| 4 | 235 | 0.59 | 0.80 | 30 | empty |
| 5 | 60 | 0.57 | 0.90 | 21 | empty |
Interfaces
6 interfaces between chains.
- C–D · 1773 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 1738 Ų buried · 16 hydrogen bonds · protein-protein
- B–D · 961 Ų buried · 17 hydrogen bonds · protein-protein
- A–C · 211 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 136 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 21 modified (engineered).
Compared structures
- 1ZWY · Crystal structure of protein VC0702 from Vibrio cholerae · the same entry in another collection · chain D against D, TM-score 1.00
- Q9KU27 · AlphaFold monomer V2.0 prediction for INOSINE/XANTHOSINE triphosphatase (Q9KU27) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9KU27
- Elsewhere: RCSB PDB 1ZWY · PDBe 1ZWY · UniProt Q9KU27
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