Research workbench
Structure of mutant kcsa potassium channel
Analyse Structure of mutant kcsa potassium channel in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ZWI
- Type
- protein
- Length
- 534 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Monoclonal antibody, heavy chain; Monoclonal antibody light chain; Voltage-gated…
- UniProt
- P0A334
- Ligands
- F09, DGA, K
- Pockets
- 5 · best druggability 0.69
Structure
x-ray diffraction · 3 distinct chains · 18% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Monoclonal antibody, heavy chain | protein | 219 | 2% helix, 46% strand | — |
| B | Monoclonal antibody light chain | protein | 212 | 7% helix, 53% strand | — |
| C | Voltage-gated potassium channel | protein | 103 | 73% helix, 0% strand | P0A334 |
Ligands and binding sites
- F09 · Nonan-1-ol · ligand · chains A, C
- DGA · Diacyl glycerol · ligand · chains C
- K · Potassium ion · metal · 7 copies · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 751 | 0.69 | 0.76 | 59 | empty |
| 2 | 252 | 0.54 | 0.77 | 43 | empty |
| 3 | 78 | 0.54 | 0.86 | 15 | empty |
| 4 | 66 | 0.50 | 0.84 | 15 | empty |
| 5 | 122 | 0.42 | 0.76 | 21 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1828 Ų buried · 16 hydrogen bonds · protein-protein
- A–C · 473 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 432 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 1ZWI · Structure of mutant KcsA potassium channel · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A334
- Elsewhere: RCSB PDB 1ZWI · PDBe 1ZWI · UniProt P0A334
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.