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Vinculin head (0-258) in complex with the talin rod residues 2345-2369

Analyse Vinculin head (0-258) in complex with the talin rod residues 2345-2369 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1ZW2
Type: protein
Length: 272 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Vinculin; Talin
UniProt: P12003
Pockets: 2 · best druggability 0.47

Structure

x-ray diffraction · 2 distinct chains · 82% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Vinculin	protein	251	82% helix, 1% strand	P12003
B	Talin	protein	21	81% helix, 0% strand	—

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	133	0.47	0.78	17	empty
2	81	0.33	0.74	16	empty

Interfaces

1 interface between chains.

A–B · 1048 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

1ZW2 · Vinculin Head (0-258) in Complex with the Talin Rod residues 2345-2369 · the same entry in another collection · chain A against A, TM-score 1.00
P12003 · AlphaFold monomer V2.0 prediction for vinculin (P12003) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P12003
Elsewhere: RCSB PDB 1ZW2 · PDBe 1ZW2 · UniProt P12003

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