Research workbench
Vinculin head (0-258) in complex with the talin rod residue 820-844
Analyse Vinculin head (0-258) in complex with the talin rod residue 820-844 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ZVZ
- Type
- protein
- Length
- 275 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Vinculin; Talin 1
- UniProt
- P12003, P54939
- Pockets
- 2 · best druggability 0.52
Structure
x-ray diffraction · 2 distinct chains · 82% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Vinculin | protein | 253 | 81% helix, 1% strand | P12003 |
| B | Talin 1 | protein | 22 | 86% helix, 0% strand | P54939 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 195 | 0.52 | 0.77 | 25 | empty |
| 2 | 104 | 0.41 | 0.77 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 1090 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 1ZVZ · Vinculin Head (0-258) in Complex with the Talin Rod Residue 820-844 · the same entry in another collection · chain A against A, TM-score 1.00
- P12003 · AlphaFold monomer V2.0 prediction for vinculin (P12003) · a predicted model of the same protein · chain A against A, TM-score 0.88
- P54939 · AlphaFold monomer V2.0 prediction for talin-1 (P54939) · a predicted model of the same protein · chain B against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12003
- Every structure of UniProt P54939
- Elsewhere: RCSB PDB 1ZVZ · PDBe 1ZVZ · UniProt P12003 · UniProt P54939
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