Research workbench
Crystal structure of the first class MHC mamu and tat-TL8 complex
Analyse Crystal structure of the first class MHC mamu and tat-TL8 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ZVS
- Type
- protein
- Length
- 770 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MHC class I antigen; Beta-2-microglobulin; Tat-TL8
- UniProt
- P61769
- Pockets
- 11 · best druggability 0.78
Structure
x-ray diffraction · 3 distinct chains · 19% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | MHC class I antigen | protein | 278 | 27% helix, 38% strand | — |
| B, E | Beta-2-microglobulin | protein | 99 | 0% helix, 49% strand | P61769 |
| C, F | Tat-TL8 | protein | 8 | 0% helix, 0% strand | — |
Pockets
11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 511 | 0.78 | 0.85 | 74 | empty |
| 2 | 734 | 0.70 | 0.77 | 65 | empty |
| 3 | 368 | 0.68 | 0.81 | 42 | empty |
| 4 | 121 | 0.45 | 0.78 | 23 | empty |
| 5 | 81 | 0.44 | 0.81 | 21 | empty |
Interfaces
7 interfaces between chains.
- A–B · 1239 Ų buried · 22 hydrogen bonds · protein-protein
- D–E · 1233 Ų buried · 21 hydrogen bonds · protein-protein
- A–C · 762 Ų buried · 20 hydrogen bonds · protein-protein
- D–F · 736 Ų buried · 20 hydrogen bonds · protein-protein
- A–D · 523 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61769
- Elsewhere: RCSB PDB 1ZVS · PDBe 1ZVS · UniProt P61769
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