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D(CTTAATTCGAATTAAG) complexed with moloney murine leukemia virus reverse transcriptase catalytic fragment

Analyse D(CTTAATTCGAATTAAG) complexed with moloney murine leukemia virus reverse… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1ZTW
Type: protein + DNA
Length: 271 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cttaattc; Gaattaag; Reverse transcriptase
EC: 2.7.7.49
UniProt: P03355
Pockets: 3 · best druggability 0.52

Structure

x-ray diffraction · 3 distinct chains · 31% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Cttaattc	dna	8	—	—
G	Gaattaag	dna	8	—	—
A	Reverse transcriptase (EC 2.7.7.49)	protein	255	31% helix, 22% strand	P03355

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	228	0.52	0.76	27	empty
2	55	0.40	0.81	11	empty
3	50	0.28	0.75	14	empty

Interfaces

3 interfaces between chains.

B–G · 350 Å² buried · 25 hydrogen bonds · nucleic-nucleic
B–A · 225 Å² buried · 4 hydrogen bonds · protein-nucleic
G–A · 205 Å² buried · 4 hydrogen bonds · protein-nucleic

Compared structures

1ZTW · d(CTTAATTCGAATTAAG) complexed with Moloney Murine Leukemia Virus Reverse Transcriptase… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03355
Elsewhere: RCSB PDB 1ZTW · PDBe 1ZTW · UniProt P03355

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