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X-ray structure of gene product from homo sapiens HS.433573

Analyse X-ray structure of gene product from homo sapiens HS.433573 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1ZTP
Type: protein
Length: 684 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Basophilic leukemia expressed protein BLES03
UniProt: Q9H3H3
Pockets: 5 · best druggability 0.69

Structure

x-ray diffraction · 3 distinct chains · 33% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Basophilic leukemia expressed protein BLES03	protein	228	35% helix, 20% strand	Q9H3H3
B	Basophilic leukemia expressed protein BLES03	protein	235	34% helix, 19% strand	Q9H3H3
C	Basophilic leukemia expressed protein BLES03	protein	221	30% helix, 20% strand	Q9H3H3

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	776	0.69	0.76	61	empty
2	638	0.66	0.76	67	empty
3	193	0.52	0.77	31	empty
4	56	0.35	0.78	16	empty
5	83	0.32	0.74	16	empty

Interfaces

3 interfaces between chains.

A–B · 1282 Å² buried · 10 hydrogen bonds · protein-protein
A–C · 217 Å² buried · 3 hydrogen bonds · protein-protein
B–C · 124 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 9 modified (engineered).

Compared structures

1ZTP · X-ray structure of gene product from homo sapiens Hs.433573 · the same entry in another collection · chain A against A, TM-score 1.00
Q9H3H3 · AlphaFold monomer V2.0 prediction for UPF0696 protein C11ORF68 (Q9H3H3) · a predicted model of the same protein · chain C against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9H3H3
Elsewhere: RCSB PDB 1ZTP · PDBe 1ZTP · UniProt Q9H3H3

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