Research workbench
Crystal structure of human heparan sulfate glucosamine 3-O- sulfotransferase 1 in complex with pap
Analyse Crystal structure of human heparan sulfate glucosamine 3-O- sulfotransferase 1… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ZRH
- Type
- protein
- Length
- 263 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heparan sulfate glucosamine 3-O-sulfotransferase 1
- EC
- 2.8.2.23
- UniProt
- O14792
- Ligands
- A3P
- Pockets
- 1 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heparan sulfate glucosamine 3-O-sulfotransferase 1 (EC 2.8.2.23) | protein | 263 | 43% helix, 16% strand | O14792 |
Ligands and binding sites
- A3P · Adenosine-3'-5'-diphosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 214 | 0.71 | 0.87 | 31 | A3P |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 1ZRH · Crystal structure of Human heparan sulfate glucosamine 3-O-sulfotransferase 1 in complex… · the same entry in another collection · chain A against A, TM-score 1.00
- O14792 · AlphaFold monomer V2.0 prediction for heparan sulfate glucosamine 3-O-sulfotransferase 1… · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14792
- Elsewhere: RCSB PDB 1ZRH · PDBe 1ZRH · UniProt O14792
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