Research workbench
IRF3-cbp complex
Analyse IRF3-cbp complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ZOQ
- Type
- protein
- Length
- 476 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interferon regulatory factor 3; Creb-binding protein
- EC
- 2.3.1.48
- UniProt
- Q14653, Q92793
- Pockets
- 6 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Interferon regulatory factor 3 | protein | 191 | 23% helix, 34% strand | Q14653 |
| C, D | Creb-binding protein (EC 2.3.1.48) | protein | 47 | 62% helix, 0% strand | Q92793 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 754 | 0.73 | 0.79 | 86 | empty |
| 2 | 259 | 0.54 | 0.76 | 37 | empty |
| 3 | 56 | 0.43 | 0.83 | 19 | empty |
| 4 | 54 | 0.39 | 0.81 | 19 | empty |
| 5 | 75 | 0.37 | 0.77 | 21 | empty |
Interfaces
5 interfaces between chains.
- B–D · 925 Ų buried · 8 hydrogen bonds · protein-protein
- A–C · 919 Ų buried · 7 hydrogen bonds · protein-protein
- A–D · 291 Ų buried · 1 hydrogen bond · protein-protein
- C–B · 261 Ų buried · 1 hydrogen bond · protein-protein
- C–D · 32 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1ZOQ · IRF3-CBP complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q14653 · AlphaFold monomer V2.0 prediction for interferon regulatory factor 3 (Q14653) · a predicted model of the same protein · chain A against A, TM-score 0.93
- Q92793 · AlphaFold monomer V2.0 prediction for creb-binding protein (Q92793) · a predicted model of the same protein · chain D against A, TM-score 0.55
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14653
- Every structure of UniProt Q92793
- Elsewhere: RCSB PDB 1ZOQ · PDBe 1ZOQ · UniProt Q14653 · UniProt Q92793
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