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NMR structure of unphosphorylated human phospholamban pentamer

Analyse NMR structure of unphosphorylated human phospholamban pentamer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1ZLL
Type: protein
Length: 260 residues
Chains: 5
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cardiac phospholamban
UniProt: P26678
Pockets: 1 · best druggability 0.78

Structure

solution nmr · 1 distinct chain · 77% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E	Cardiac phospholamban	protein	52	77% helix, 0% strand	P26678

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	586	0.78	0.83	45	empty

Interfaces

5 interfaces between chains.

D–E · 462 Å² buried · 0 hydrogen bonds · protein-protein
C–D · 457 Å² buried · 0 hydrogen bonds · protein-protein
A–E · 450 Å² buried · 0 hydrogen bonds · protein-protein
B–C · 443 Å² buried · 0 hydrogen bonds · protein-protein
A–B · 401 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

1ZLL · NMR Structure of Unphosphorylated Human Phospholamban Pentamer · the same entry in another collection · chain A against A, TM-score 1.00
P26678 · AlphaFold monomer V2.0 prediction for cardiac phospholamban (P26678) · a predicted model of the same protein · chain A against A, TM-score 0.49

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P26678
Elsewhere: RCSB PDB 1ZLL · PDBe 1ZLL · UniProt P26678

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