Research workbench
Crystal structure of the mycobacterium tuberculosis hypoxic response regulator dosr C-terminal domain-DNA complex
Analyse Crystal structure of the mycobacterium tuberculosis hypoxic response regulator… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ZLK
- Type
- protein + DNA
- Length
- 179 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5'- D(*GP*GP*CP*CP*CP*GP*CP*GP*CP*TP*TP*TP*GP*GP*GP*GP*AP*CP*TP…
- Pockets
- 3 · best druggability 0.58
Structure
x-ray diffraction · 3 distinct chains · 55% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | 5'- D(*GP*GP*CP*CP*CP*GP*CP*GP*CP*TP*TP*TP*GP*GP*GP*GP*AP*CP*TP *AP*AP*AP*GP*TP*CP*CP*CP*TP*AP*AP*CP*CP*CP*TP*GP*GP*CP*CP*A P*CP*GP*AP*T)-3' | dna | 24 | — | — |
| D | 5'- D(*CP*GP*TP*GP*GP*CP*CP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*AP*CP *TP*TP*TP*AP*GP*TP*CP*CP*CP*CP*AP*AP*AP*GP*CP*GP*CP*GP*GP*G P*CP*CP*AP*T)-3' | dna | 25 | — | — |
| A, B | Dormancy survival regulator | protein | 65 | 55% helix, 0% strand | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 160 | 0.58 | 0.83 | 22 | empty |
| 2 | 101 | 0.41 | 0.77 | 16 | empty |
| 3 | 94 | 0.39 | 0.77 | 17 | empty |
Interfaces
6 interfaces between chains.
- C–D · 997 Ų buried · 76 hydrogen bonds · nucleic-nucleic
- A–B · 528 Ų buried · 5 hydrogen bonds · protein-protein
- C–A · 397 Ų buried · 10 hydrogen bonds · protein-nucleic
- D–B · 394 Ų buried · 6 hydrogen bonds · protein-nucleic
- C–B · 377 Ų buried · 8 hydrogen bonds · protein-nucleic
Compared structures
- 1ZLK · Crystal Structure of the Mycobacterium tuberculosis Hypoxic Response Regulator DosR… · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 1ZLK · PDBe 1ZLK
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