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A superhelical spiral in escherichia COLI DNA gyrase a C- terminal domain imparts unidirectional supercoiling bias

Analyse A superhelical spiral in escherichia COLI DNA gyrase a C- terminal domain… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1ZI0
Type: protein
Length: 583 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA gyrase subunit a
EC: 5.99.1.3
UniProt: P09097
Pockets: 4 · best druggability 0.70

Structure

x-ray diffraction · 2 distinct chains · 8% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA gyrase subunit a (EC 5.99.1.3)	protein	287	7% helix, 43% strand	P09097
B	DNA gyrase subunit a (EC 5.99.1.3)	protein	296	9% helix, 42% strand	P09097

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	807	0.70	0.76	62	empty
2	823	0.68	0.75	59	empty
3	93	0.46	0.80	25	empty
4	115	0.38	0.74	17	empty

Interfaces

1 interface between chains.

A–B · 424 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

1ZI0 · A Superhelical Spiral in Escherichia coli DNA Gyrase A C-terminal Domain Imparts… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P09097
Elsewhere: RCSB PDB 1ZI0 · PDBe 1ZI0 · UniProt P09097

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