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Solution structure of the human MMS2-ubiquitin complex

Analyse Solution structure of the human MMS2-ubiquitin complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1ZGU
Type: protein
Length: 215 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ubiquitin-conjugating enzyme E2 variant 2; Ubiquitin
UniProt: Q15819, P61864
Pockets: 2 · best druggability 0.36

Structure

solution nmr · 2 distinct chains · 25% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ubiquitin-conjugating enzyme E2 variant 2	protein	139	26% helix, 19% strand	Q15819
B	Ubiquitin	protein	76	24% helix, 34% strand	P61864

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	55	0.36	0.79	15	empty
2	60	0.30	0.75	16	empty

Interfaces

1 interface between chains.

A–B · 657 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

1ZGU · Solution structure of the human Mms2-Ubiquitin complex · the same entry in another collection · chain A against A, TM-score 1.00
Q15819 · AlphaFold monomer V2.0 prediction for ubiquitin-conjugating enzyme E2 variant 2 (Q15819) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q15819
Every structure of UniProt P61864
Elsewhere: RCSB PDB 1ZGU · PDBe 1ZGU · UniProt Q15819 · UniProt P61864

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