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Crystal structure of a pathogenic RNA: cug repeats

Analyse Crystal structure of a pathogenic RNA: cug repeats in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1ZEV
Type: RNA
Length: 36 nucleotides
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 5'-R(*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*G) -3'
Pockets: 1 · best druggability 0.59

Structure

x-ray diffraction · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	5'-R(CPUPGPCPUPGPCPUPGPCPUPGPCPUPGPCPUPG) -3'	rna	18	—	—

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	540	0.59	0.74	26	empty

Interfaces

1 interface between chains.

A–B · 878 Å² buried · 95 hydrogen bonds · nucleic-nucleic

Compared structures

1ZEV · Crystal Structure of a Pathogenic RNA: CUG Repeats · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 1ZEV · PDBe 1ZEV

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