Research workbench
Crystal structure of RV2827C protein from mycobacterium tuberculosis
Analyse Crystal structure of RV2827C protein from mycobacterium tuberculosis in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ZEL
- Type
- protein
- Length
- 588 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hypothetical protein RV2827C
- UniProt
- Q7D6H9
- Ligands
- NA
- Pockets
- 4 · best druggability 0.45
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hypothetical protein RV2827C | protein | 293 | 45% helix, 12% strand | Q7D6H9 |
| B | Hypothetical protein RV2827C | protein | 295 | 43% helix, 12% strand | Q7D6H9 |
Ligands and binding sites
- NA · Sodium ion · metal · 2 copies · chains A, B
- FMT · Formic acid · additive · 15 copies · chains A, B
- ACT · Acetate ion · additive · 2 copies · chains B
- MPD · (4S)-2-methyl-2,4-pentanediol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 133 | 0.45 | 0.76 | 31 | FMT |
| 2 | 175 | 0.43 | 0.74 | 25 | empty |
| 3 | 84 | 0.39 | 0.77 | 22 | ACT |
| 4 | 51 | 0.27 | 0.74 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 127 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 1ZEL · Crystal structure of RV2827C protein from Mycobacterium tuberculosis · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7D6H9
- Elsewhere: RCSB PDB 1ZEL · PDBe 1ZEL · UniProt Q7D6H9
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