Research workbench
Crystal structure of the complex formed between signalling protein from goat mammary gland (spg-40) and a tripeptide TRP-pro-TRP at 2.8A resolution
Analyse Crystal structure of the complex formed between signalling protein from goat… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ZBW
- Type
- protein
- Length
- 364 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chitinase-3 like protein 1; Wpw
- UniProt
- Q8SPQ0
- Ligands
- NAG
- Pockets
- 4 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chitinase-3 like protein 1 | protein | 361 | 37% helix, 24% strand | Q8SPQ0 |
| D | Wpw | protein | 3 | 0% helix, 0% strand | — |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 289 | 0.66 | 0.82 | 46 | empty |
| 2 | 264 | 0.56 | 0.77 | 24 | empty |
| 3 | 88 | 0.33 | 0.74 | 18 | empty |
| 4 | 54 | 0.30 | 0.76 | 16 | empty |
Interfaces
1 interface between chains.
- A–D · 247 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 1ZBW · Crystal structure of the complex formed between signalling protein from goat mammary… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8SPQ0 · AlphaFold monomer V2.0 prediction for chitinase-3-like protein 1 (Q8SPQ0) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8SPQ0
- Elsewhere: RCSB PDB 1ZBW · PDBe 1ZBW · UniProt Q8SPQ0
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