Research workbench
Crystal structure of the native CHAPERONE:SUBUNIT:SUBUNIT CAF1M:CAF1:CAF1 complex
Analyse Crystal structure of the native CHAPERONE:SUBUNIT:SUBUNIT CAF1M:CAF1:CAF1… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1Z9S
- Type
- protein
- Length
- 473 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chaperone protein CAF1M; F1 capsule antigen
- UniProt
- P26926, P26948
- Pockets
- 4 · best druggability 0.61
Structure
x-ray diffraction · 3 distinct chains · 3% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chaperone protein CAF1M | protein | 196 | 3% helix, 57% strand | P26926 |
| B | F1 capsule antigen | protein | 149 | 2% helix, 52% strand | P26948 |
| C | F1 capsule antigen | protein | 128 | 2% helix, 49% strand | P26948 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 181 | 0.61 | 0.84 | 34 | empty |
| 2 | 281 | 0.53 | 0.75 | 46 | empty |
| 3 | 60 | 0.42 | 0.82 | 17 | empty |
| 4 | 147 | 0.40 | 0.73 | 29 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1787 Ų buried · 46 hydrogen bonds · protein-protein
- B–C · 1141 Ų buried · 32 hydrogen bonds · protein-protein
- A–C · 275 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 1Z9S · Crystal Structure of the native chaperone:subunit:subunit Caf1M:Caf1:Caf1 complex · the same entry in another collection · chain A against A, TM-score 1.00
- P26926 · AlphaFold monomer V2.0 prediction for chaperone protein CAF1M (P26926) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P26948 · AlphaFold monomer V2.0 prediction for F1 capsule antigen (P26948) · a predicted model of the same protein · chain C against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P26926
- Every structure of UniProt P26948
- Elsewhere: RCSB PDB 1Z9S · PDBe 1Z9S · UniProt P26926 · UniProt P26948
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