Research workbench
X-ray crystal structure of protein CV1439 from chromobacterium violaceum. northeast structural genomics consortium target CVR12.
Analyse X-ray crystal structure of protein CV1439 from chromobacterium violaceum.… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1Z94
- Type
- protein
- Length
- 851 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Conserved hypothetical protein
- UniProt
- Q7NY36
- Pockets
- 12 · best druggability 0.78
Structure
x-ray diffraction · 4 distinct chains · 24% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Conserved hypothetical protein | protein | 140 | 24% helix, 44% strand | Q7NY36 |
| B | Conserved hypothetical protein | protein | 144 | 24% helix, 42% strand | Q7NY36 |
| C, D, F | Conserved hypothetical protein | protein | 143 | 24% helix, 46% strand | Q7NY36 |
| E | Conserved hypothetical protein | protein | 138 | 25% helix, 44% strand | Q7NY36 |
Pockets
12 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1194 | 0.78 | 0.80 | 81 | empty |
| 2 | 342 | 0.74 | 0.85 | 38 | empty |
| 3 | 354 | 0.73 | 0.84 | 34 | empty |
| 4 | 422 | 0.71 | 0.82 | 39 | empty |
| 5 | 315 | 0.71 | 0.83 | 31 | empty |
Interfaces
6 interfaces between chains.
- A–D · 1003 Ų buried · 10 hydrogen bonds · protein-protein
- B–C · 998 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 636 Ų buried · 10 hydrogen bonds · protein-protein
- C–D · 629 Ų buried · 9 hydrogen bonds · protein-protein
- E–F · 613 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 13 modified (engineered).
Compared structures
- 1Z94 · X-Ray Crystal Structure of Protein CV1439 from Chromobacterium violaceum. Northeast… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7NY36
- Elsewhere: RCSB PDB 1Z94 · PDBe 1Z94 · UniProt Q7NY36
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