Research workbench
ATP phosphoribosyl transferase (hiszg ATP-prtase) from lactococcus lactis
Analyse ATP phosphoribosyl transferase (hiszg ATP-prtase) from lactococcus lactis in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1Z7M
- Type
- protein
- Length
- 2,048 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP phosphoribosyltransferase regulatory subunit; ATP phosphoribosyltransferase
- EC
- 2.4.2.17
- UniProt
- Q02147, Q02129
- Ligands
- PO4, WO4
- Pockets
- 20 · best druggability 0.88
Structure
x-ray diffraction · 8 distinct chains · 40% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ATP phosphoribosyltransferase regulatory subunit | protein | 311 | 44% helix, 19% strand | Q02147 |
| B | ATP phosphoribosyltransferase regulatory subunit | protein | 318 | 44% helix, 19% strand | Q02147 |
| C | ATP phosphoribosyltransferase regulatory subunit | protein | 302 | 45% helix, 20% strand | Q02147 |
| D | ATP phosphoribosyltransferase regulatory subunit | protein | 314 | 44% helix, 20% strand | Q02147 |
| E | ATP phosphoribosyltransferase (EC 2.4.2.17) | protein | 200 | 35% helix, 29% strand | Q02129 |
| F | ATP phosphoribosyltransferase (EC 2.4.2.17) | protein | 201 | 34% helix, 28% strand | Q02129 |
| G | ATP phosphoribosyltransferase (EC 2.4.2.17) | protein | 203 | 33% helix, 29% strand | Q02129 |
| H | ATP phosphoribosyltransferase (EC 2.4.2.17) | protein | 199 | 33% helix, 28% strand | Q02129 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · 6 copies · chains E, F, G, H, B, D
- WO4 · Tungstate(vi)ion · ion · 2 copies · chains A, G, C, D, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1043 | 0.88 | 0.89 | 114 | PO4 |
| 2 | 1135 | 0.86 | 0.87 | 121 | PO4 |
| 3 | 443 | 0.79 | 0.87 | 60 | empty |
| 4 | 405 | 0.76 | 0.86 | 57 | empty |
| 5 | 392 | 0.76 | 0.86 | 57 | empty |
Interfaces
20 interfaces between chains.
- C–D · 2082 Ų buried · 12 hydrogen bonds · protein-protein
- A–B · 1997 Ų buried · 15 hydrogen bonds · protein-protein
- E–F · 1124 Ų buried · 7 hydrogen bonds · protein-protein
- B–G · 1122 Ų buried · 18 hydrogen bonds · protein-protein
- D–F · 1066 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 1Z7M · ATP Phosphoribosyl transferase (HisZG ATP-PRTase) from Lactococcus lactis · the same entry in another collection · chain H against H, TM-score 1.00
- Q02129 · AlphaFold monomer V2.0 prediction for ATP phosphoribosyltransferase (Q02129) · a predicted model of the same protein · chain E against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q02147
- Every structure of UniProt Q02129
- Elsewhere: RCSB PDB 1Z7M · PDBe 1Z7M · UniProt Q02147 · UniProt Q02129
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.